First off I will state this is from the PC version, so these issue may not affect XB1.
#1 I found that with K&M when sending a unit around the edges of the map, the unit can actually go off the map (most noticable with flying units) and you cannot select the unit again without using the “all units” option which can be a pain when you have multiple of the same unit.
#2 Using the Cobras lockdown can sometimes be buggy, I have told it to lockdown near another locked down Cobra, there was plenty of space, and it started moving away going somewhere random on the map. This has happened multiple times, sometimes if you do a lockdown while the Cobra is in the middle of the screen it makes the issue go away.
#3 Hitboxes, when clicking on parts of your base when you don’t have it in the middle of your screen with K&M you often select another part of the base, because the selection hitbox for the mouse seems to be too big.
#4 This might be a bug, but yesterday I was playing the final campaign mission and the objective arrows were pointing to the wrong airlocks.